At the location of the former Upfront building and the Pacific Heaven Cafe, is now a big pharmacy / drugstore chain called "Drug Papas" (どらっくぱぱす). They opened on 7/16 and are having a grand opening / coupon sale. They were also hiring part-timers last month. They own the building's address now and are calling their location "Papas Akabanebashi Ekimae Store". They have many store locations.
I don't know if they using the entire building or just the first floor.